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Europe
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America
South
America
United States
Status: Issued
Patent #: 5,753,506 and 6,040,180
Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals (div)
United States
Status: Issued
Patent #: 6,284,539
Method for generating dopaminergic cells derived from neural precursors
United States
Status: Issued
Patent #: 8,846,914
Compositions and Methods of Use
United States
Status: Issued
Patent #: 7,544,511
Stable neural stem cell lines (div)
United States
Status: Issued
Patent #: 7,560,553 and 7,858,628
Use of fused nicotinamides to promote neurogenesis (div)
Ann Arbor, Michigan: FDA-approved NSI-566/ALS Phase II trial, which expanded to three centers including ALS Clinic at University of Michigan Health System, concluded in 1Q15. Larger, controlled, registration directed NSI-566/ALS clinical trial expected to commence in 2016. More
Boston: Neurogenic NSI-189/Phase II Major Depressive Disorder study first patient enrollment expected in 1Q 2016. FDA-approved Phase Ia and Ib were completed 4Q13, with data presented in June 2014. More
Boston: FDA-approved NSI-566/ALS Phase II trial, which expanded to three centers including Massachusetts General Hospital, concluded in 1Q15. Larger, controlled, registration directed NSI-566/ALS clinical trial expected to commence in 2016. More
United States
Status: Issued
Patent #: 7,691,629
Methods of treating spinal cord injury (div)
United States
Status: Pending
Application #: 12/404,841, and 12/710,097
Methods of treating spinal cord injury (div)
United States
Status: Pending
Application #: 11/852,922
Method for discovering neurogenic agents
United States
Status: Pending
Application #: 61/368,409
Methods for treating and/or reversing neurodegenerative diseases and/or disorders
United States
Status: Exclusive Worldwide License to Patent #: 8,092,495
Spinal Platform and Method for Delivering a Therapeutic Agent to a Spinal Cord Target
United States
Status: Pending
Application #: 12/424,238
Stable neural stem cell lines (div)
United States
Status: Issued
Patent #: 8,030,492
Compositions to effect neuronal growth
United States
Status: Exclusive Worldwide License to Issued Patents
Patent #: 7,833,217
Patent #: 8,708,962
Floating Spinal Cannula and Method of Use
United States
Status: Issued
Patent #: 8,058,434
Compositions to effect neuronal growth
United States
Status: Issued
Patent #: 8,236,299
Transplantation of human neural cells for treatment of neurodegenerative conditions
Canada
Status: Pending
Application #: 2343571
Stable neural stem cell lines
Canada
Status: Pending
Application #: 2257068
Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
United Kingdom
Status: Issued
Patent #: 0915968
Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
Switzerland
Status: Issued
Patent #: 0915968
Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
Sweden
Status: Issued
Patent #: 0915968
Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
Spain
Status: Issued
Patent #: 0915968
Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
Ireland
Status: Issued
Patent #: 0915968
Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
Germany
Status: Issued
Patent #: 69737949.3
Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
France
Status: Issued
Patent #: 0915968
Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
Norway
Status: Pending
Application #: 20073078
Methods of treating spinal cord injury
Federation of Russia
Status: Pending
Application #: 2007122507
Methods of treating spinal cord injury
European Patent Organisation (EPO)
Status: Pending
Application #: 99948396.9
Stable neural stem cell lines
European Patent Organisation (EPO)
Status: Pending
Application #: 037903564
Method for discovering neurogenic agents
European Patent Organisation (EPO)
Status: Pending
Application #: 05851748.3
Methods of treating spinal cord injury
Australia
Status: Issued
Patent #: 755849
Stable neural stem cell lines
Singapore
Status: Issued
Patent #: 132324
Methods of treating spinal cord injury
Japan
Status: Issued
Patent #: 4709382
Stable neural stem cell lines (div)
Japan
Status: Pending
Application #: 2007-543219
Methods of treating spinal cord injury
Japan
Status: Pending
Application #: 2010-254952
Stable neural stem cell lines (div)
Vietnam
Status: Pending
Application #: 1-2007-01216
Methods of treating spinal cord injury
South Korea
Status: Issued
Patent #:10-14929284
Methods of Treating Spinal Cord Injury
Philippines
Status: Pending
Application #: 1-2007-501016 and 1-2010-502167
Methods of treating spinal cord injury (div)
India
Status: Pending
Application #: 2613/CHENP/2007
Methods of treating spinal cord injury
China
Status: Pending
Application #: 200580039450
Methods of treating spinal cord injury
Hong Kong
Status: Pending
Application #: 8106303.1
Methods of treating spinal cord injury
Israel
Status: Pending
Application #: 183092
Methods of treating spinal cord injury (div)
Israel
Status: Pending
Application #: 204356
Methods of treating spinal cord injury (div)
United Arab Emirates
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Antigua and Barbuda
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Albania
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Armenia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Angola
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Austria
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Australia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Azerbaijan
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Bosnia and Herzegovina
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Barbados
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Belgium
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Burkina Faso
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Bulgaria
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Bahrain
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Benin
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Brazil
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Botswana
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Belarus
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Belize
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Canada
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Central African Republic
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Congo
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Switzerland
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Côte d'Ivoire
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Chile
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Cameroon
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
China
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Colombia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Costa Rica
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Cuba
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Cyprus
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Czech Republic
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Germany
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Denmark
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Dominica
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Dominican Republic
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Algeria
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Ecuador
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Estonia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Egypt
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Spain
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Finland
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
France
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Gabon
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
United Kingdom
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Grenada
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Georgia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Ghana
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Gambia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Guinea
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Equatorial Guinea
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Greece
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Guatemala
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Guinea-Bissau
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Honduras
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Croatia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Hungary
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Indonesia
Status: Issued
Patent #:108142605
Synthesis of a neurostimulative piperazine
Ireland
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Israel
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
India
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Iceland
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Italy
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Japan
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Kenya
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Kyrgyzstan
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Comoros
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Saint Kitts and Nevis
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Korea, Democratic People's Republic of
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Korea, Republic of
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Kazakhstan
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Lao People's Democratic Republic
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Saint Lucia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Liechtenstein
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Sri Lanka
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Liberia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Lesotho
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Lithuania
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Luxembourg
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Latvia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Libyan Arab Jamahiriya
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Morocco
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Monaco
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Moldova, Republic of
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Montenegro
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Madagascar
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Macedonia, the former Yugoslav Republic of
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Mali
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Mongolia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Mauritania
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Malta
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Malawi
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Mexico
Status: Issued
Patent #:323079
Synthesis of a neurostimulative piperazine
Malaysia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Mozambique
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Namibia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Niger
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Nigeria
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Nicaragua
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Netherlands
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Norway
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
New Zealand
Status: Issued
Patent #:598891
Synthesis of a neurostimulative piperazine
Oman
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Peru
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Papua New Guinea
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Philippines
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Poland
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Portugal
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Romania
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Serbia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Russian Federation
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Russian Federation
Status: Issued
Stem cell transplantation to treat neurodegenerative conditions
Seychelles
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Sudan
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Sweden
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Singapore
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Slovenia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Slovakia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Sierra Leone
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
San Marino
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Senegal
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Sao Tome and Principe
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
El Salvador
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Syrian Arab Republic
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Swaziland
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Chad
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Togo
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Thailand
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Tajikistan
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Turkmenistan
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Tunisia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Turkey
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Trinidad and Tobago
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Tanzania, United Republic of
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Ukraine
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Uganda
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
United States
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Uzbekistan
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Saint Vincent and the Grenadines
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Vietnam
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
South Africa
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Zambia
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Zimbabwe
Status: Pending
Application #: PCT/US2010/046537
Synthesis of a neurostimulative piperazine
Atlanta: FDA-approved NSI-566/ALS Phase II trial, which expanded to three centers including Emory University Hospital, site of Phase I, concluded in 1Q15. Larger, controlled, registration directed NSI-566/ALS clinical trial expected to commence in 2016. More
San Diego: FDA-approved NSI-566/chronic spinal cord injury Phase I four-patient trial completed the last surgery in July 2015, with six-month post-observation period, at University of California, San Diego School of Medicine. More
Suzhou: Neuralstem China 神脑生物医药公司 (Suzhou Neuralstem Biopharmaceutical Company, Ltd.), a wholly owned subsidiary, launched in June 2010 with the intention of conducting stem cell clinical trials in the People’s Republic of China. More
Beijing: Phase I/II trial to treat ischemic stroke using NSI-566 spinal cord stem cells commenced in December 2013, in collaboration with BaYi Brain Hospital in Beijing. Phase II/controlled proof-of-concept study commencement expected in 2016. More
Seoul: Acute SCI Phase I/II Trial awaiting IND approval. CJ CheilJedang has an exclusive option agreement for cell therapy products in South Korea and five additional South Asian countries. More
Indonesia: Neuralstem has an exclusive option agreement with CJ CheilJedang, for cell therapy products in South Korea, Indonesia, Malaysia, Philippines, Singapore and Vietnam. More
Malaysia: Neuralstem has an exclusive option agreement with CJ CheilJedang, for cell therapy products in South Korea, Indonesia, Malaysia, Philippines, Singapore and Vietnam. More
Philippines: Neuralstem has an exclusive option agreement with CJ CheilJedang, for cell therapy products in South Korea, Indonesia, Malaysia, Philippines, Singapore and Vietnam. More
Singapore: Neuralstem has an exclusive option agreement with CJ CheilJedang, for cell therapy products in South Korea, Indonesia, Malaysia, Philippines, Singapore and Vietnam. More
Vietnam: Neuralstem has an exclusive option agreement with CJ CheilJedang, for cell therapy products in South Korea, Indonesia, Malaysia, Philippines, Singapore and Vietnam. More