Publications: Neuralstem Technology
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Reversal of Radiation-induced Cognitive Impairment by Oral Administration of Neurogenic Small Molecule Compound NSI-189 Authors: Barrett D. Allen, Munjal M. Archarya, Celine Lu, Erich Giedzinski, Vipan K. Parihar, Mike Heffran, Karl K. Johe, Charles L. Limoli
Radiation Research Society Annual Meeting, October 19, 2017 -
Therapeutic Efficacy of NSI-189 in Diabetic Mice Authors: Karl Johe1, Alex Marquez2, Carlos Anaya2, BetelhemKifle2, NabeelMuttalib2, Corinne G. Jolivalt2, Mike Hefferan1, Nigel A. Calcutt2, 1Neuralstem, Inc; 2Department of Pathology, UCSD
Annual Meeting of the Diabetic Neuropathy Study Group of the EASD (European Association for the Study of Diabetes), held in Bucharest, Romania. -
Intraspinal stem cell transplantation for amyotrophic lateral sclerosis Authors: Kevin S. Chen, MD, Stacey A. Sakowski, PhD, and Eva L. Feldman, MD, PhD
Annals of Neurology, Article first published online: February 12, 2016. -
A Phase 1B, Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Escalation Study of NSI-189 Phosphate, a Neurogenic Compound, in Depressed Patients Authors: M Fava, K Johe, L Ereshefsky, L G Gertsik, B A English, J A Bilello, L M Thurmond, J Johnstone, B C Dickerson, N Makris, B B Hoeppner, M Flynn, D Mischoulon, G Kinrys, and M P Freeman. Massachusetts General Hospital, Clinical Trials and Network Institute; Harvard Medical School, Department of Psychiatry; Neuralstem, Inc., PAREXEL International, California Clinical Trials Medical Group, Ridge Diagnostics, Q-Metrx, Inc., Center for Morphometric Analysis, Massachusetts General Hospital
Molecular Psychiatry, Article first published online: December 8, 2015. -
Human Neural Stem Cells Expressing IGF-1: A Novel Cellular Therapy for Alzheimer’s Disease Authors: Lisa M. McGinley, Osama N. Kashlan, Kevin S. Chen, Carey Backus, Crystal Pacut, Stacey A. Sakowski, Karl Johe, Eva L. Feldman; Department of Neurology, University of Michigan (U-M), Department of Neurosurgery, U-M, A. Alfred Taubman Biomedical Research Institute, U-M, Neuralstem, Inc.
International Society for Stem Cell Research (ISSCR) Annual Meeting, Stockholm, Sweden, Poster presented June 25, 2015. -
Biomarker Profiling of NSI-189 Phosphate, a Neurogenic Compound, in Patients with Major Depressive Disorder (MDD) during a Phase Ib Randomized Double-Blind, Placebo-Controlled Trial Authors: J. A. Bilello, X. Feng, L.M. Thurmond, L. Gertsik, B.A. English, L. Ereshefsky. M. Fava, B. Hoeppner, M. Flynn, D. Mischoulon, G. Kinrys, M. Freeman, and K. Johe. Ridge Diagnostics, San Diego, CA; California Clinical Trials Medical Group, Glendale, CA; PAREXEL International, Glendale, CA. Harvard Medical School, Clinical Trials Network & Institute (CTNI), Massachusetts General Hospital, Boston, MA; Neuralstem, Inc., Germantown, MD
CNS Summit, Poster presented November 14, 2014. -
Analysis of graft survival in a trial of stem cell transplant in ALS Authors: Tezeta Tadesse, Marla Gearing, David Senitzer, Debra Saxe, Daniel J. Brat, Robert Bray, Howard Gebel, Charles Hill, Nicholas Boulis, Jonathan Riley, Eva Feldman, Karl Johe, Thomas Hazel, Meraida Polak, Jane Bordeau, Thais Federici and Jonathan D. Glass
Annals of Clinical and Translational Neurology, Article first published online: October 22, 2014. -
Effects of NSI-189, a neurogenic compound, on quantitative electroencephalography (qEEG) in patients with major depressive disorder (MDD) during a phase 1b randomized, double-blind, placebo controlled, multiple ascending dose study Authors: Brett English, PharmD, PhD, Jack Johnstone, PhD, Karl Johe, PhD, Lev Gertsik, MD, Molly Sherman, Maurizio Fava, MD Larry Ereshefsky, PharmD
The International College of Neuropsychopharmacology (CINP), Abstract posted June 17, 2014, in advance of presentation at 29th CINP World Congress of Neuropsychopharmacology: June 24, 2014. -
A Phase 1B, Randomized, Double-Blind, Placebo-Controlled, Multiple-Dose Escalation Study Evaluating the Effects of NSI-189 Phosphate, a Neurogenic Compound, in Patients with Major Depressive Disorder (MDD) Authors: Maurizio Fava, MD, Karl Johe, PhD, Lev G. Gertsik, MD, Larry Ereshefsky PharmD, Bettina Hoeppner, PhD, Martina Flynn, David Mischoulon, MD, PhD, Gustavo Kinrys, MD, and Marlene Freeman, MD
American Society of Clinical Psychopharmacology (formerly NCDEU), Abstract posted May 23, 2014, in advance of oral presentation at ASCP Annual Meeting: June 17, 2014. -
Behavioral and Histopathological Assessment of Adult Ischemic Rat Brains after Intracerebral Transplantation of NSI-566RSC Cell Lines Authors: Naoki Tajiri, David M. Quach, Yuji Kaneko, Stephanie Wu, David Lee, Tina Lam, Ken L. Hayama, Thomas G. Hazel, Karl Johe, Michael C. Wu, Cesar V. Borlongan
PLOS ONE, Published: March 10, 2014, DOI: 10.1372/journal.pone.0091408. -
Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: Phase 1 trial outcomes Authors: Eva L. Feldman MD, PhD, Nicholas M. Boulis MD, PhD, Junguk Hur PhD, Karl Johe PhD, Seward B. Rutkove MD, Thais Federici PhD, Meraida Polak RN, Jane Bordeau RN, Stacey A. Sakowski PhD and Jonathan D. Glass MD
Annals of Neurology, March 2014 -
Transplantation of human fetal-derived neural stem cells improves cognitive function following cranial irradiation Authors: Munjal M. Acharya; Lori-Ann Christie; Thomas G. Hazel; Karl K. Johe; Charles L. Limoli
Cell Transplantation: The Regenerative Medicine Journal, Volume 23, Number 10, 2014,
Pages 1255-1266(12); E-pub August 2013. -
Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation Authors: Sebastiaan van Gorp, Marjolein Leerink, Osamu Kakinohana, Oleksandr Platoshyn, Camila Santucci, Jan Galik, Elbert A. Joosten, Marian Hruska-Plochan, Danielle Goldberg, Silvia Marsala, Karl Johe, Joseph D. Ciacci, Martin Marsala
Stem Cell Research and Therapy, Volume 4, Issue 5(4.57), 28 May 2013. -
Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury Authors: Paul Lu, Yaozhi Wang, Lori Graham, Karla McHale, Mingyong Gao, Di Wu, John Brock, Armin Blesch, Ephron S. Rosenzweig, Leif A. Havton, Binhai Zheng, James M. Conner, Martin Marsala, Mark H. Tuszynski
Cell, Volume 150, Issue 6, 14 September 2012, Pages 1264-1273.
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Lumbar Intraspinal Injection of Neural Stem Cells in Patients with ALS: Results of a Phase I Trial in 12 Patients Authors: Glass JD, Boulis NM, Johe K, Rutkove SB, Federici T, Polak M, Kelly C, Feldman, EL, Department of Neurology, Emory University School of Medicine, Atlanta
Stem Cells, 2012 Jun;30(6):1144-51.
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Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitry Authors: Xu L, Ryugo DK, Pongstaporn T, Johe K, Koliatsos VE, Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore
The Journal of Comparative Neurology, 2009 Jun 1;514(4):297-309.
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Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cord. Authors: Yan J, Xu L, Welsh AM, Hatfield G, Hazel T, Johe K, Koliatsos VE, Department of Pathology, Division of Neuropathology, The Johns Hopkins Medical Institutions, Baltimore
PLoS Medicine, 2007 Feb;4(2):e39.
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Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells. Authors: Cizkova D, Kakinohana O, Kucharova K, Marsala S, Johe K, Hazel T, Hefferan MP, Marsala M, Institute of Neurobiology, Centrum of Excellence, Slovak Academy of Science, Kosice, Soltesovej 4, Slovakia.
Neuroscience, 2007 Jun 29;147(2):546-60. Epub 2007 May 23.
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Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic mice. Authors: Yan J, Xu L, Welsh AM, Chen D, Hazel T,
Johe K, Koliatsos VE, Department of Pathology, Neuropathology Division, The Johns Hopkins University School of Medicine, BaltimoreStem cells (Dayton, Ohio), 2006 Aug;24(8): 1976-85. Epub 2006 Apr 27.